Protein Details: Potassium voltage-gated channel subfamily E member 1

Protein ID

ICDB_Pro_0350

Protein Name

Potassium voltage-gated channel subfamily E member 1

Gene Name

Kcne1

Organism

Rattus norvegicus (Rat)

Length

130 amino acids

AlphaFoldDB

AF-P15383-F1-model_v4.pdb

Function

Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. Assembled with KCNQ1/KVLQT1 is proposed to form the slowly activating delayed rectifier cardiac potassium (IKs) channel. The outward current reaches its steady state only after 50 seconds. Assembled with KCNH2/HERG may modulate the rapidly activating component of the delayed rectifying potassium current in heart (IKr) (By similarity)

Sequence

MALSNSTTVLPFLASLWQETDEPGGNMSADLARRSQLRDDSKLEALYILMVLGFFGFFTLGIMLSYIRSKKLEHSHDPFNVYIESDAWQEKGKALFQARVLESFRACYVIENQAAVEQPATHLPELKPLS

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Expressed in the heart (PubMed:19219384; PubMed:2183220). Expressed in kidney (PubMed:2344412). Expressed in estrogen-induced uterus (PubMed:2344412).

DOI ID

10.1126/science.3194754; 10.1073/pnas.87.8.2975; 10.1016/0896-6273(90)90207-v; 10.1093/oxfordjournals.jbchem.a123181; 10.1126/science.1553557; 10.1016/0896-6273(95)90277-5; 10.1074/jbc.m310501200; 10.1007/s00232-009-9154-8

RefSeq

NP_037105.1; XP_006248096.1; XP_006248097.1; XP_008766788.1; XP_017453375.1; XP_017453376.1